國家衛生研究院 NHRI:Item 3990099045/4820
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/4820


    Title: Effective reduction of gastric cancer risk with regular use of nonsteroidal anti-inflammatory drugs in helicobacter pylori-infected patients
    Authors: Wu, CY;Wu, MS;Kuo, KN;Wang, CB;Chen, YJ;Lin, JT
    Contributors: Division of Health Policy Research and Development
    Abstract: PURPOSE Nonsteroidal anti-inflammatory drugs (NSAIDs) play protective roles in gastric carcinogenesis. However, the interaction between NSAIDs and Helicobacter pylori (H pylori) infection and the number needed to treat to prevent gastric cancer remains unclear. PATIENTS AND METHODS We conducted a nationwide retrospective cohort study based on data from the Taiwan National Health Insurance Database. Hospitalized patients with a primary diagnosis of peptic ulcer disease were selected. Overall, 52,161 patients were divided into non-NSAID user and regular NSAID user cohorts. Standardized incidence ratios (SIRs), cumulative incidences, and hazard ratios (HRs) were calculated. Results Patients with peptic ulcers who never used NSAIDs had higher risk of gastric cancer compared with the general population (SIR, 2.11; 95% CI, 2.07 to 2.15), but regular NSAID use conferred lower risk (SIR, 0.79; 95% CI, 0.77 to 0.81). The protective role of NSAID use was observed in patients with gastric ulcer, but not in patients with non-H pylori-associated duodenal ulcer. On multivariate analysis, regular NSAID use was an independent protective factor for gastric cancer development (HR, 0.79 for each incremental year; P < .001), especially in H pylori-associated patients (HR, 0.52 for each incremental year; P < .001). Among patients with H pylori-infected gastric ulcers, the NNT to prevent a gastric cancer was 50. CONCLUSION Regular NSAID use may be a feasible way to prevent gastric cancer, at least in patients with gastric ulcers, and especially in H pylori-infected subjects.
    Date: 2010-06
    Relation: Journal of Clinical Oncology. 2010 Jun;28(18):2952-2957.
    Link to: http://dx.doi.org/10.1200/jco.2009.26.0695
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0732-183X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000278883200006
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77954613539
    Appears in Collections:[Ken-Nan Kuo] Periodical Articles
    [Jaw-Town Lin] Periodical Articles

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