國家衛生研究院 NHRI:Item 3990099045/4831
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    题名: Cytotoxic C35 terpenoid cryptotrione from the bark of cryptomeria japonica
    作者: Chen, CC;Wu, JH;Yang, NS;Chang, JY;Kuo, CC;Wang, SY;Kuo, YH
    贡献者: National Institute of Cancer Research
    摘要: A novel C35-terpene, designated as cryptotrione (1), with an unprecedented skeleton possessing an abietane diterpene with a unique bicyclic sesquiterpene, is identified from the bark of Cryptomeria japonica. The carbon skeleton of 1 represents a new structural entity, and this is an intriguing addition to the structurally diverse diterpene-sesquiterpene class. A unique biosynthetic pathway is proposed to support the production of this phytocompound. Notably, 1 exhibits anticancer activity with an IC50 value of 6.44 ± 2.23 μM.
    日期: 2010-06-18
    關聯: Organic Letters. 2010 Jun;12(12):2786-2789.
    Link to: http://dx.doi.org/10.1021/ol1009027
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1523-7060&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000278616800028
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77953564925
    显示于类别:[郭靜娟] 期刊論文
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