國家衛生研究院 NHRI:Item 3990099045/4851

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Title:	Chitosan hydrogel as an immunoisolative barrier for xenogeneic islet transplantation
Other Titles:	3rd International Conference on the Development of Biomedical Engineering in Vietnam
Authors:	Yang, KC;Qi, Z;Lin, FH;Wu, CC;Sumi, S
Contributors:	Division of Medical Engineering Research
Abstract:	Chitosan hydrogel was utilized as an immunoisolative barrier to facilitate the xenogeneic islets transplantation without immunosuppression. Rat islets were encapsulated in chitosan hydrogel and transplanted into the renal subcapsular space of diabetic mice. Non-fasting blood glucose level (NFBG), and body weight were recorded perioperatively. Mice were sacrificed at predetermined intervals and kidney transplanted with islets/chitosan hydrogel was retrieved for histologic examination. Results showed that the NFBG of mice transplanted with islets/chitosan hydrogel maintained in the range of 148-242 mg/dl for four weeks with increased body weight. Histologic sections revealed that the islets successfully engrafted at renal subcapsular space with positive insulin staining. This study indicates that the chitosan hydrogel protects encapsulated islets successfully during xenotransplantation.
Date:	2010-01-11
Relation:	IFMBE Proceedings. 2010 11 January 2010 through 14 January 2010;27:179-181.
Link to:	http://dx.doi.org/10.1007/978-3-642-12020-6_44
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000307677500044
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77952392493
Appears in Collections:	[Feng-Huei Lin] Conference Papers/Meeting Abstract

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