國家衛生研究院 NHRI:Item 3990099045/4922
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    题名: Is impaired energy regulation the core of the metabolic syndrome in various ethnic groups of the USA and Taiwan?
    作者: Wahlqvist, ML;Chang, HY;Chen, CC;Hsu, CC;Chang, WC;Wang, WS;Hsiung, CA
    贡献者: Division of Health Policy Research and Development;Division of Biostatistics and Bioinformatics
    摘要: ABSTRACT: BACKGROUND: The metabolic syndrome (MetS) concept is widely used in public health and clinical settings without an agreed pathophysiology. We have re-examined the MetS in terms of body fuels, so as to provide a coherent cross-cultural pathogenesis. METHODS: National Health and Nutrition Examination Survey (NHANES 2001-2) with n = 2254 and Taiwanese National Health Interview Survey (NHIS) sub-set for hypertension, hyperglycemia and hyperlipidemia assessment (TwSHHH 2002), n = 5786, were used to compare different ethnicities according to NCEP-ATPIII (NCEP-tw) criteria for METS. Exploratory factor analysis (EFA) using principal components (PC) was employed to differentiate and unify MetS components across four ethnicities, gender, age-strata, and urban-rural settings. RESULTS: The first two factors from the PC analysis (PCA) accounted for from 55.2% (non-Hispanic white) to 63.7% (Taiwanese) of the variance. Rotated factor loadings showed that the six MetS components provided three clusters: the impaired energy regulation (IER) components (waist circumference, WC, fasting triglycerides, TG, and fasting plasma glucose, FPG), systolic and diastolic blood pressures (BPs), and HDL-cholesterol, where the IER components accounted for 25-26% of total variance of MetS components. For the three US ethnic subgroups, factor 1 was mainly determined by IER and HDL-cholesterol, and factor 2 was related to the BP components. For Taiwanese, IER was determinant for both factors, and BPs and HDL-cholesterol were related to factors 1 and 2 respectively. CONCLUSIONS: There is a MetS core which unifies populations. It comprises WC, TG and FPG as a core, IER, which may be expressed and modulated in various second order ways.
    日期: 2010-06
    關聯: BMC Endocrine Disorders. 2010 Jun;10:Article number 11.
    Link to: http://dx.doi.org/10.1186/1472-6823-10-11
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1472-6823&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000297286200001
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77952870897
    显示于类别:[熊昭] 期刊論文
    [MARK LAWRENCE WAHLQVIST(2008-2012)] 期刊論文
    [張新儀] 期刊論文
    [許志成] 期刊論文

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