國家衛生研究院 NHRI:Item 3990099045/4943
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    題名: Tri-functionalization of mesoporous silica nanoparticles for comprehensive cancer theranostics-the trio of imaging, targeting and therapy
    作者: Cheng, SH;Chen, MC;Lee, CH;Souris, JS;Tseng, FG;Mou, CY;Yang, CS;Chen, CT;Lo, LW
    貢獻者: Division of Medical Engineering Research;Center for Nanomedicine Research
    摘要: In this work we report the development of the tri-functionalized mesoporous silica nanoparticles (MSNs) for use as theranostic compounds that orchestrate the trio of imaging, target and therapy in a single particle. The MSNs are functionalized in sequence with (1) contrast agents that enable traceable imaging of particle targeting, (2) drug payloads for therapeutic intervention and, (3) biomolecular ligands for highly-targeted particle delivery. Traceable imaging of nanoparticles was accomplished by directly incorporating a near-infrared (NIR) fluorescent contrast agent, ATTO647N, into the silica framework of MSNs, to exploit the relative transparency of most tissues at NIR wavelengths and maximize MSN surface area available for the subsequent conjugating drugs and targeting ligands. An oxygen-sensing, palladium-porphyrin based photosensitizer (Pd-porphyrin; PdTPP) was incorporated into the MSN's nanochannels, to enable photodynamic therapy (PDT). cRGDyK peptides, tiling the outermost surfaces of MSNs, were used for targeting the overexpressed v 3 integrins of cancer cells, and to ensure the internalization of the photosensitizer PdTPP. In vitro cell evaluation of the theranostic platform demonstrated not only excellent targeting specificity and minimal collateral damage, but highly potent therapeutic effect as well.
    日期: 2010-08
    關聯: Journal of Materials Chemistry. 2010 Aug;20(29):6149-6157.
    Link to: http://dx.doi.org/10.1039/C0JM00645A
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000279852000022
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77954637738
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