國家衛生研究院 NHRI:Item 3990099045/4956
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    题名: Maintenance of duplicate genes and their functional redundancy by reduced expression
    作者: Qian, WF;Liao, BY;Chang, AY;Zhang, JZ
    贡献者: Division of Biostatistics and Bioinformatics
    摘要: Although evolutionary theories predict functional divergence between duplicate genes, many old duplicates still maintain a high degree of functional similarity and are synthetically lethal or sick, an observation that has puzzled many geneticists. We propose that expression reduction, a special type of subfunctionalization, facilitates the retention of duplicates and the conservation of their ancestral functions. Consistent with this hypothesis, gene expression data from both yeasts and mammals show a substantial decrease in the level of gene expression after duplication. Whereas the majority of the expression reductions are likely to be neutral, some are apparently beneficial to rebalancing gene dosage after duplication.
    日期: 2010-10
    關聯: Trends in Genetics. 2010 Oct;26(10):425-430.
    Link to: http://dx.doi.org/10.1016/j.tig.2010.07.002
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0168-9525&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000282403200001
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77956781437
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