The total synthesis of natural lignans 5'-methoxyyatein (1), 5'-methoxyclusin (2), and 4'-hydroxycubebinone (3), in racemic form, has been achieved by a newly developed strategy, wherein lithium naphthalenide induced decyanation was employed as a key operation to establish the essential trans configuration of the butyrolactone ring.
Date:
2010-06
Relation:
European Journal of Organic Chemistry. 2010 Jun;2010(18):3473-3480.
