國家衛生研究院 NHRI:Item 3990099045/4960
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    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/4960


    题名: Discovery of 1-(2,4-Dichlorophenyl)-4-ethyl-5-(5-(2-(4-(trifluoromethyl)phenyl)ethynyl)thiophe n-2-yl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide as a potential peripheral cannabinoid-1 receptor inverse agonist
    作者: Hung, MS;Chang, CP;Li, TC;Yeh, TK;Song, JS;Lin, Y;Wu, CH;Kuo, PC;Amancha, PK;Wong, YC;Hsiao, WC;Chao, YS;Shia, KS
    贡献者: Division of Biotechnology and Pharmaceutical Research
    摘要: Fast food nation! The title compound (pictured) was identified as a potential peripheral CB1-acting antagonist based on its negative central effects in CB1R agonist-induced hypothermia and analgesia models, and low brain exposure as indicated by the blood-to-plasma ratio. This compound represents a potential lead in the treatment of metabolic disorders.
    日期: 2010-09
    關聯: ChemMedChem. 2010 Sep;5(9):1439-1443.
    Link to: http://dx.doi.org/10.1002/cmdc.201000246
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1860-7179&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000281918400004
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77956411564
    显示于类别:[夏克山] 期刊論文
    [趙宇生(2002-2013)] 期刊論文
    [葉燈光] 期刊論文
    [洪明秀] 期刊論文
    [張竣評] 期刊論文

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