國家衛生研究院 NHRI:Item 3990099045/4968
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    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/4968


    题名: Endogenous latent membrane protein 1 in Epstein-Barr virus-infected nasopharyngeal carcinoma cells attracts T lymphocytes through upregulation of multiple chemokines
    作者: Lai, HC;Hsiao, JR;Chen, CW;Wu, SY;Lee, CH;Su, IJ;Takada, K;Chang, Y
    贡献者: Division of Infectious Diseases
    摘要: Tumor-infiltrating T lymphocytes are considered to facilitate development of Epstein-Barr virus (EBV)-associated nasopharyngeal carcinoma (NPC), but how EBV in NPC tumor cells directs T cell infiltration remains unclear. Here we compare EBV-infected NPC cells with and without spontaneous expression of viral latent membrane protein 1 (LMP1) and find that culture supernatants of LMP1-positive NPC cells exert enhanced chemoattraction to primary T cells. Knockdown of endogenous LMP1 in the cells suppresses the chemotactic activity. Endogenous LMP1 in NPC cells upregulates multiple chemokines, among which MIP-1α, MIP-1β and IL-8 contribute to T cell chemotaxis. We further reveal that LMP1-induced production of MIP-1α and MIP-1β in NPC cells requires not only two carboxyl-terminal activation regions of LMP1 but also their downstream NF-κB and JNK pathways. This study corroborates that endogenous LMP1 in EBV-infected NPC cells induces multiple chemokines to promote T cell recruitment and perhaps other pathogenic events in NPC.
    日期: 2010-09
    關聯: Virology. 2010 Sep;405(2):464-473.
    Link to: http://dx.doi.org/10.1016/j.virol.2010.06.037
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0042-6822&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000281130500022
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77955653371
    显示于类别:[張堯] 期刊論文
    [蘇益仁(2002-2015)] 期刊論文

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