國家衛生研究院 NHRI:Item 3990099045/4977

NHRI > National Institute of Environmental Health Sciences > Huei Lee(2009-2011) > Periodical Articles > Item 3990099045/4977

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/4977

Title:	XRCC1, but not APE1 and hOGG1 gene polymorphisms is a risk factor for pterygium
Authors:	Chen, PL;Yeh, KT;Tsai, YY;Koeh, H;Liu, YL;Lee, H;Cheng, YW
Contributors:	Division of Environmental Health and Occupational Medicine
Abstract:	Purpose: Epidemiological evidence suggests that UV irradiation plays an important role in pterygium pathogenesis. UV irradiation can produce a wide range of DNA damage. The base excision repair (BER) pathway is considered the most important pathway involved in the repair of radiation-induced DNA damage. Based on previous studies, single-nucleotide polymorphisms (SNPs) in 8-oxoguanine glycosylase-1 (OGG1), X-ray repair cross-complementing-1 (XRCC1), and AP-endonuclease-1 (APE1) genes in the BER pathway have been found to affect the individual sensitivity to radiation exposure and induction of DNA damage. Therefore, we hypothesize that the genetic polymorphisms of these repair genes increase the risk of pterygium. Methods: XRCC1, APE1, and hOGG1 polymorphisms were studied using fluorescence-labeled Taq Man probes on 83 pterygial specimens and 206 normal controls. Results: There was a significant difference between the case and control groups in the XRCC1 genotype (p=0.038) but not in hOGG1 (p=0.383) and APE1 (p=0.898). The odds ratio of the XRCC1 A/G polymorphism was 2.592 (95% CI=1.225-5.484, p=0.013) and the G/G polymorphism was 1.212 (95% CI=0.914-1.607), compared to the A/A wild-type genotype. Moreover, individuals who carried at least one C-allele (A/G and G/G) had a 1.710 fold increased risk of developing pterygium compared to those who carried the A/A wild type genotype (OR=1.710; 95% CI: 1.015-2.882, p=0.044). The hOGG1 and APE1 polymorphisms did not have an increased odds ratio compared with the wild type. Conclusions: XRCC1 (Arg399 Glu) is correlated with pterygium and might become a potential marker for the prediction of pterygium susceptibility.
Date:	2010-06-04
Relation:	Molecular Vision. 2010 Jun;16:991-996.
Link to:	http://www.molvis.org/molvis/v16/a109/
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1090-0535&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000279676600003
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77955607933
Appears in Collections:	[Huei Lee(2009-2011)] Periodical Articles

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