國家衛生研究院 NHRI:Item 3990099045/4982
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    題名: Biological monitoring for occupational acrylamide exposure from acrylamide production workers
    作者: Huang, YF;Wu, KY;Liou, SH;Uang, SN;Chen, CC;Shih, WC;Lee, SC;Huang, CCJ;Chen, ML
    貢獻者: Division of Environmental Health and Occupational Medicine;Division of Biostatistics and Bioinformatics
    摘要: Objective :We conducted a repeated-measurement study to (1) investigate the correlation between occupational exposure to airborne acrylamide (AA) and the time-dependent behavior of urinary AAMA, GAMA2, and GAMA3 and (2) calculate the estimated biological exposure index at the permissible exposure limit (PEL) level of 30 μg/m3.Methods :Forty-four workers were recruited—8 were AA-exposed and 36 were controls. Pre- and post-shift urine samples were collected from the exposed group in parallel with personal sampling for 8 consecutive days and only 1 day for the control group and analyzed using liquid chromatography-electrospray ionization/tandem mass spectrometry (LC–ESI–MS/MS). Results :Post-shift urinary AAMA level was significantly associated with personal AA exposure (p < 0.001), indicating that urinary AAMA was a better AA exposure biomarker. The estimated urinary excretion of AAMA was 3.0 mg/g creatinine for nonsmoking workers exposed to the PEL of 30 μg/m3. The median GAMA (the sum of GAMA2 and GAMA3)/AAMA ratio for exposed workers was 0.03 (range, 0.005–0.14), relatively lower than that of the nonoccupational group. Conclusions :Although sample size in this study was small, the repeated-measurement data provide useful reference for future studies related to biological monitoring of occupational exposure to AA.
    日期: 2011-03
    關聯: International Archives of Occupational and Environmental Health. 201 Mar;84(3):303-313.
    Link to: http://dx.doi.org/10.1007/s00420-010-0558-7
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0340-0131&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000287247400009
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79955966753
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