國家衛生研究院 NHRI:Item 3990099045/4987
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/4987


    Title: Modulation of the development of human monocyte-derived dendritic cells by lithium chloride
    Authors: Liu, KJ;Lee, YL;Yang, YY;Shih, NY;Ho, CC;Wu, YC;Huang, TS;Huang, MC;Liu, HC;Shen, WW;Leu, SJ
    Contributors: National Institute of Cancer Research
    Abstract: Lithium has been used or explored to treat psychiatric and neurodegenerative diseases that are frequently associated with an abnormal immune status. It is likely that lithium may work through modulation of immune responses in these patients. Because dendritic cells (DC) play a central role in regulating immune responses, this study investigated the influence of lithium chloride (LiCl) on the development and function of DC. Exposure to LiCl during the differentiation of human monocyte-derived immature DCs (iDC) enhances CD86 and CD83 expression and increases the production of IL-1beta, IL-6, IL-8, IL-10 and TNF-alpha. However, the presence of LiCl during LPS-induced maturation of iDC has the opposite effect. During iDC differentiation, LiCl suppresses the activity of glycogen synthase kinase (GSK)-3beta, and activates PI3K and MEK. In addition, LiCl activates peroxisome proliferator-activated receptor gamma (PPARgamma) during iDC differentiation, a pathway not described before. Each of these signaling pathways appears to have distinct impact on the differentiating iDC. The enhanced CD86 expression by LiCl involves the PI3K/AKT and GSK-3beta pathway. LiCl modulates the expression of CD83 in iDC mainly through MEK/ERK, PI3K/AKT and PPARgamma pathways, while the increased production of IL-1beta and TNF-alpha mainly involves the MEK/ERK pathway. The effect of LiCl on IL-6/IL-8/IL-10 secretion in iDC is mediated through inhibition of GSK-3beta. We have also demonstrated that PPARgamma is downstream of GSK-3beta and is responsible for the LiCl-mediated modulation of CD86/83 and CD1 expression, but not IL-6/8/10 secretion. The combined influence of these molecular signaling pathways may account for certain clinical effect of lithium.
    Date: 2011-02
    Relation: Journal of Cellular Physiology. 2010 Feb;226(2):424-433.
    Link to: http://dx.doi.org/10.1002/jcp.22348
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0021-9541&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000286352600016
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=78649641162
    Appears in Collections:[Tze-Sing Huang] Periodical Articles
    [Ko-Jiunn Liu] Periodical Articles
    [Neng-Yao Shih] Periodical Articles

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