國家衛生研究院 NHRI:Item 3990099045/5024
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    题名: Identifying conserved DR1501-restricted CD4+ T cell epitopes in avian H5N1 hemagglutinin proteins
    作者: Wang, SF;Chen, KH;Yao, L;Lee, YM;Chan, YJ;Liu, SJ;Chong, P;Liu, WJ;Huang, JC;Chen, YM
    贡献者: Vaccine Research and Development Center
    摘要: Highly pathogenic avian influenza H5N1 viruses are capable of causing poultry epidemics and human mor-tality. Vaccines that induce protective neutralizing antibodies can prevent outbreaks and decrease the potential for influenza A pandemics. Identifying unique H5N1 virus-specific HLA class II-restricted epitopes is essential for monitoring cellular strain-specific immunity. Our results indicate that 80% of the 30 study participants who were inoculated with an H5N1 vaccine produced neutralizing antibodies. We used intracellular cytokine staining (ICS) to screen and identify six DR1501-restricted H5N1 virus epitopes: H5HA148–162, H5HA155–169, H5HA253–267, H5HA260–274, H5HA267–281 and H5HA309–323. Tetramer staining results confirmed that two immunodominant epitopes were DR1501-restricted: H5HA155–169 and H5HA267–281. Both are located at the HA surface and are highly conserved in currently circulating H5N1 clades. These results suggest that a combination of ICS and tetramer staining can be used as a T-cell epitope-mapping platform, and the identified epitopes may serve as markers for monitoring vaccine efficacy.
    日期: 2010-12
    關聯: Viral Immunology. 2010 Dec;23(6):585-593.
    Link to: http://dx.doi.org/10.1089/vim.2010.0058
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0882-8245&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000285093300006
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=78650114721
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