國家衛生研究院 NHRI:Item 3990099045/5040
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    题名: Fast quantification of the exhaled breath condensate of oxidative stress 8-iso-prostaglandin F2alpha using on-line solid-phase extraction coupled with liquid chromatography/electrospray ionization mass spectrometry
    其它题名: Fastquantification of the exhaledbreathcondensate of oxidativestress 8-iso-prostaglandin F2α using on-line solid-phase extraction coupled with liquid chromatography/electrospray ionization mass spectrometry
    作者: Wang, CJ;Yang, NH;Liou, SH;Lee, HL
    贡献者: Division of Environmental Health and Occupational Medicine
    摘要: A method using automated on-line solid-phase extraction (SPE) liquid chromatography-electrospray tandem mass spectrometry (LC-ESI-MS/MS) for the determination of 8-iso-PGF2α in human exhaled breath condensate (EBC) was developed and validated. A C18 SPE column with an affinity sorbent was used for on-line extraction. A C18 column was employed for LC separation and ESI-MS/MS was utilized for detection. 8-iso-PGF2α-d<sub>4</sub> was used as an internal standard for quantitative determination. The extraction, cleanup and analysis procedures were controlled by a fully automated six-port switch valve. Identification and quantification were based on the following transitions: m/z 353 → 193 for 8-iso-PGF2α and m/z 357 → 197 for 8-iso-PGF2α-d<sub>4</sub>, respectively. Good recoveries from 98.94 to 99.86% were measured and satisfactory linear ranges for these analytical compounds were determined. Intra-day and inter-day precision showed that coefficients of variance (CV) ranged from 6.5 to 8.0% and 5.2 to 6.3%, respectively. The applicability of this newly developed method was demonstrated by analyzing human EBC samples for an evaluation of the future risk of human exposure to nanoparticles.
    日期: 2010-09-15
    關聯: Talanta. 2010 Sep 15;82(4):1434-1438
    Link to: http://dx.doi.org/10.1016/j.talanta.2010.07.015
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0039-9140&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000282480500051
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77956188159
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