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http://ir.nhri.org.tw/handle/3990099045/5048
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| Title: | A phase II and pharmacokinetic study of first line S-1 for advanced gastric cancer in Taiwan |
| Authors: | Chen, JS;Chao, Y;Hsieh, RK;Cheng, AL;Chen, PM;Chiou, TJ;Chao, TY;Yeh, KH;Chen, LT;Whang-Peng, J |
| Contributors: | National Institute of Cancer Research |
| Abstract: | PURPOSE: To evaluate the efficacy, safety and pharmacokinetic profiles of S-1, which composed of tegafur (FT, a prodrug of 5-FU), 5-chloro-2,4-dihydroxypyridine and potassium oxonate (Oxo), in Taiwanese advanced gastric cancer (AGC) patients. METHODS: Patients with chemo-naive, histologically confirmed AGC were eligible. S-1 was given orally at dose of 40, 50 or 60 mg, twice daily for patients with body surface <1.25, 1.25-1.5 and >1.5 m(2), respectively, on day 1-28 every 42 days/cycle. RESULTS: Thirty-four patients were included. On intent-to-treat analysis, the overall response rate, median progression-free and overall survival were 35.3% [95% confidence interval (CI): 19.2-51.3%], 2.9 (95% CI: 2.4-5.8) months and 9.8 (95% CI: 6.1-NA) months, respectively. The most common grade 3-4 toxicities were anemia 23.5% and neutropenia 11.8%. There were two treatment-related mortality, which occurred in patients with suboptimal renal function underestimated by serum creatinine level at study entry. Single-dose pharmacokinetic study showed trend toward lower AUC(5-FU), and higher AUC(FT) and AUC(Oxo) comparing to most Western reports. CONCLUSIONS: The efficacy, toxicity and pharmacokinetic profiles of S-1 in current study are compatible with those from other Asian populations. Accurate renal function assessment and more closely monitoring is mandatory for S-1 therapy in patients with low body mass. Literature review suggests that, besides AUC(5-FU), AUC(Oxo) may also attribute to the difference in the compliance to S-1 between Asian and Caucasian populations. |
| Date: | 2011-08-17 |
| Relation: | Cancer Chemotherapy and Pharmacology. 2011 Aug 17;67(6):1281-1289. |
| Link to: | http://dx.doi.org/10.1007/s00280-010-1416-8 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0344-5704&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000291036500008 |
| Cited Times(Scopus): | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79959581533 |
| Appears in Collections: | [陳立宗] 期刊論文
[彭汪嘉康(1996-2007)] 期刊論文
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Size | Format | |
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| PB2010090213.pdf | | 263Kb | Adobe PDF | 715 | View/Open |
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