國家衛生研究院 NHRI:Item 3990099045/5086
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/5086


    Title: Hepatitis B genotype C correlated with poor surgical outcomes for hepatocellular carcinoma
    Authors: Liang, TJ;Mok, KT;Liu, SI;Huang, SF;Chou, NH;Tsai, CC;Chen, IS;Yeh, MH;Chen, YC;Wang, BW
    Contributors: Division of Molecular and Genomic Medicine
    Abstract: Background: Genotype B and C are the predominant hepatitis B virus (HBV) strains in Taiwan. We aimed to investigate the role of genotype in HBV-related hepatocellular carcinoma (HCC) after resection. Study design: From October 2005 to November 2008, 64 patients who underwent liver resection for HBV-related HCC were enrolled. HBV genotypes were determined by molecular method. Patient characteristics, biochemical, tumor, and viral factors were evaluated for their prognostic significance. Results: During a mean follow-up of 26.6 ? 13.2 months, patients infected with genotype C had higher HBV viral load (p = 0.007) and worse disease-free survival rate (p = 0.028) than patients with genotype B. By univariate analysis, genotype C, alanine transaminase >50 U/L, tumor size ?5 cm, and microvascular invasion were associated with tumor recurrence. Further multivariate analysis demonstrated genotype C remained a significant risk factor (p = 0.034). Conclusions: Genotype C is a strong risk factor for HCC recurrence after resection. More intensive monitoring for recurrence should be considered in patients with genotype C.
    Date: 2010-11
    Relation: Journal of the American College of Surgeons. 2010 Nov;211(5):580-586.
    Link to: http://dx.doi.org/10.1016/j.jamcollsurg.2010.06.020
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1072-7515&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000284297400002
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=78049373681
    Appears in Collections:[Shiu-Feng Kathy Huang] Periodical Articles

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