國家衛生研究院 NHRI:Item 3990099045/5116
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    题名: Peroxisome proliferator-activated receptors protect against apoptosis via 14-3-3
    作者: Wu, KK
    贡献者: Institute of Cellular and Systems Medicine
    摘要: Peroxisome proliferator-activated receptors (PPARs) were reported to prevent cells from stress-induced apoptosis and protect tissues against ischemia-reperfusion injury. The underlying transcriptional mechanism is unclear. Recent reports indicate that the antiapoptotic actions of ligand-activated PPARdelta and PPARgamma are mediated through enhanced binding of PPAR to the promoter of 14-3-3epsilon and upregulation of 14-3-3epsilon expression. We propose that ligand-activated PPARalpha exerts its anti-apoptotic actions via the identical pathway. The PPAR to 14-3-3 transcriptional axis plays an important role in protection of cell and tissue integrity and is a target for drug discovery.
    日期: 2010
    關聯: PPAR research. 2010;(2010):Article number 417646.
    Link to: http://dx.doi.org/10.1155/2010/417646
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1687-4757&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000283421700001
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77957960820
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