國家衛生研究院 NHRI:Item 3990099045/5240
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    题名: Silica-modified Fe-doped calcium sulfide nanoparticles for in vitro and in vivo cancer hyperthermia
    作者: Wu, SYH;Yang, KC;Tseng, CL;Chen, JC;Lin, FH
    贡献者: Division of Medical Engineering Research
    摘要: In this study, sulfide-based magnetic Fe-doped CaS nanoparticles modified with a silica layer were investigated for cancer hyperthermia. A polyvinyl pyrrolidone polymer was used as the coupling agent. The developed nanoparticles contained 11.6 wt% iron concentration, and their X-ray diffraction pattern was similar to those of CaS and Fe-CaS nanoparticles. The average particle size was approximately 47.5 nm and homogeneously dispersed in aqueous solutions. The major absorption bands of silica were observed from the FTIR spectrum. The magnetic properties and heating efficiency were also examined. The specific absorption ratio of nanoparticles at a concentration of 10 mg/mL at 37°C in an ethanol carrier fluid was 37.92 W/g, and the nanoparticles would raise the temperature to over 45°C within 15 min. A cytotoxicity analysis revealed that the nanoparticles had good biocompatibility, which indicated that the nanoparticles did not affect cell viability. The therapeutic effects of the nanoparticles were investigated using in vitro and animal studies. Cells seeded with nanoparticles and treated under an AC magnetic field revealed a percentage of cytotoxicity (60%) that was significantly higher from that in other groups. In the animal study, during a hyperthermia period of 15 days, tumor-bearing Balb/c mice that were subcutaneously injected with nanoparticles and exposed to an AC magnetic field manifested a reduction in tumor volume. The newly developed silica-modified Fe-CaS nanoparticles can thus be considered a promising and attractive hyperthermia thermoseed.
    日期: 2011-03
    關聯: Journal of Nanoparticle Research. 2011 Mar;13(3):1139-1149.
    Link to: http://dx.doi.org/10.1007/s11051-010-0106-0
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1388-0764&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000289003000023
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79956125837
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