國家衛生研究院 NHRI:Item 3990099045/5292
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    题名: Cd/Se/Te-based quantum dot 705 modulated redox homeostasis with hepatotoxicity in mice
    作者: Lin, CH;Yang, MH;Chang, LW;Yang, CS;Chang, H;Chang, WH;Tsai, MH;Wang, CJ;Lin, Pp
    贡献者: Division of Environmental Health and Occupational Medicine;Center for Nanomedicine Research
    摘要: The objective of this study was to investigate whether quantum dot 705 (QD705) disrupts the cellular antioxidant systems leading to hepatotoxicity in mice. Mice were intravenously injected with QD705 and then sacrificed at week 12 or 16. Homeostasis of antioxidant-related metals, antioxidant activities, induction of oxidative stress, and toxicity in the liver were investigated. Although no histopathological change was observed, a time- and dose-dependent increase in metallothionein expression and reduction in liver function was noticed. Increased copper, zinc, and selenium levels and enhancements of the trace metal-corresponding transporters were noted at week 12. At week 16, a decline of selenium from its elevated level at week 12 was observed, which was accompanied by changes in glutathione peroxidase activity as well as in redox status. A significant reduction in superoxide dismutase activity was observed at 16 weeks. Furthermore, a corresponding elevation of heme oxygenase-1 expression, 8-oxo-7,8-dihydro-2′-deoxyguanosine, interleukin-6 and tumor necrosis factor-alpha suggested the presence of oxidative stress, oxidative DNA damage and inflammation.
    日期: 2011-12
    關聯: Nanotoxicology. 2011 Dec:5(4):650-663.
    Link to: http://dx.doi.org/10.3109/17435390.2010.539712
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1743-5390&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000296633100016
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=80655128383
    显示于类别:[林嬪嬪] 期刊論文
    [張惠華(1999-2009)] 期刊論文
    [楊重熙] 期刊論文

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