國家衛生研究院 NHRI:Item 3990099045/5307
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    题名: X-ray synthesized PEGylated (polyethylene glycol coated) gold nanoparticles in mice strongly accumulate in tumors
    作者: Wang, CH;Liu, CJ;Chien, CC;Chen, HT;Hua, TE;Leng, WH;Chen, HH;Kempson, IM;Hwu, Y;Hsiao, M;Lai, TC;Wang, JL;Yang, CS;Lin, HM;Chen, YJ;Margaritondo, G
    贡献者: Center for Nanomedicine Research
    摘要: The spatial distribution of X-ray synthesized, PEG coated Au nanoparticles in cancer-bearing mice and their time dependent accumulation were investigated with inductive coupled plasma - optical emission spectroscopy (ICP-OES), transmission electron microscopy (TEM) and histological imaging. The results conclusively demonstrate that the particles strongly accumulate in tumor regions; up to ?25 times more than in normal muscle tissue. This accumulation increases with the time after injection for up to ?12 h in tumor, spleen and liver tissues, whereas for most non-tumor regions it saturates or decreases (blood, lung, brain, heart, and kidney). The impact of this result is discussed with special emphasis on passive targeted drug delivery and could also be used for the delineation and early-stage imaging of small tumors.
    日期: 2011-03
    關聯: Materials Chemistry and Physics. 2011 Mar;126(1-2):352-356.
    Link to: http://dx.doi.org/10.1016/j.matchemphys.2010.11.014
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0254-0584&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000287349600056
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=78751630389
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