A series of 7-arylindoline-1-benzenesulfonamides were prepared and evaluated for anticancer activity 7-(4'-Cyanophenyl)indoline-1-benzenesulfonamide 15 exhibited substantial antiproliferative activity with IC50 values ranging from 17-32 nM against a variety of human cancer cell lines, including MDR resistant line Compound 15 (IC50 = 1 5 mu M) also showed more potent inhibition of tubulin polymerization than 4a (combretastatin A-4. IC50 = 2 0 mu M) and displayed strong binding to the colchicine binding site of the tubulin
