國家衛生研究院 NHRI:Item 3990099045/5348
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    题名: Tumor-associated macrophage: Its role in tumor angiogenesis
    作者: Lee, CC;Liu, KJ;Huang, TS
    贡献者: National Institute of Cancer Research
    摘要: Macrophages are important cells in wound healing, providing aids for tissue cell growth, tissue matrix remodeling and angiogenesis. Solid tumor comprises not only tumor cells, but also tissue matrix and many stromal cells such as fibroblasts and macrophages. Accumulating research results have suggested tumor-associated macrophages (TAMs) functioning in tumor cell proliferation, tumor cell migration and invasion, and tumor angiogenesis. In this review article, we review data from clinical investigations and animal studies to demonstrate the association of TAMs with tumor angiogenesis. We also discuss results of several mechanistic studies to provide possible mechanisms for TAMs-associated angiogenesis. By interacting with cancer cells, TAMs can be induced to express more cytokines and tissue matrix-degrading enzymes, such as matrix metalloproteinases, plasminogen activators and cathepsin B, that are either direct angiogenic factors or tissue matrix modulators responsible for promoting tumor angiogenesis. The angiogenic effect of TAMs can be neutralized by antagonizing antibodies or competitive soluble receptors of interleukin-6, interleukin-8 and tumor necrosis factor-alpha, suggesting the involvement of these cytokines in TAMs-associated angiogenesis. With evidence indicating TAM's tumor-promoting roles, many investigations have been undertaken to study the potential of using TAMs as the therapeutic target. Photosensitizer can be labeled to the scavenger receptor class A to target TAMs in cancer photodynamic therapy. In addition, macrophages can be engineered to serve as vehicles to carry drug or genes to the hypoxic areas of tumor. More detailed mechanisms regarding the interaction between TAMs and tumor still need to be explored, and a thorough understanding of this interaction will provide some helpful conceptual suggestions for the future cancer therapy.
    日期: 2006-08
    關聯: Journal of Cancer Molecules. 2006 Aug;2(4):135-140.
    Link to: http://mupnet.com/JOCM%202%284%29%20135.htm
    显示于类别:[劉柯俊] 期刊論文
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