國家衛生研究院 NHRI:Item 3990099045/5356
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/5356


    Title: Structural and mechanical properties of klebsiella pneumoniae type 3 fimbriae
    Authors: Chen, FJ;Chan, CH;Huang, YJ;Liu, KL;Peng, HL;Chang, HY;Liou, GG;Yew, TR;Liu, CH;Hsu, KY;Hsu, L
    Contributors: Division of Molecular and Genomic Medicine
    Abstract: This study investigated the structural and mechanical properties of Klebsiella pneumoniae type 3 fimbriae, which constitute a known virulence factor for the bacterium. Transmission electron microscopy and optical tweezers were used to understand the ability of the bacterium to survive flushes. An individual K. pneumoniae type 3 fimbria exhibited a helix-like structure with a pitch of 4.1 nm and a three-phase force-extension curve. The fimbria was first nonlinearly stretched with increasing force. Then, it started to uncoil and extended several micrometers at a fixed force of 66 +/- 4 pN (n = 22). Finally, the extension of the fimbria shifted to the third phase with a characteristic force of 102 +/- 9 pN (n = 14) at the inflection point. Compared with the P fimbriae and type 1 fimbriae of uropathogenic Escherichia coli, K. pneumoniae type 3 fimbriae have a larger pitch in the helix-like structure and stronger uncoiling and characteristic forces.
    Date: 2011-01
    Relation: Journal of Bacteriology. 2011 Jan;193(7):1718-1725.
    Link to: http://dx.doi.org/10.1128/jb.01395-10
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0021-9193&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000288314400024
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79952801204
    Appears in Collections:[Gan-Guang Liou(2006-2014)] Periodical Articles

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