國家衛生研究院 NHRI:Item 3990099045/5374
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    题名: Surface expression of HLA-G is involved in mediating immunomodulatory effects of placenta-derived multipotent cells (PDMCs) towards natural killer lymphocytes
    作者: Liu, KJ;Wang, CJ;Chang, CJ;Hu, HI;Hsu, PJ;Wu, YC;Bai, CH;Sytwu, HK;Yen, BL
    贡献者: Institute of Cellular and Systems Medicine;National Institute of Cancer Research
    摘要: Interactions between maternal natural killer lymphocytes (NKs) and fetal tissues are important in mediating maternal-fetal tolerance. We therefore investigated the interactions of NKs to placenta-derived multipotent cells (PDMCs) isolated from the term human placenta. PDMCs have similar cell surface marker expression as BMMSCs and additionally express human embryonic stem cell markers SSEA-4 and CD-9. Differentiation into the tri-mesodermal lineages of osteoblastic, adipocytic, and chondrogenic phenotypes can be readily achieved under the appropriate conditions. We found that PDMCs are more resistant to NK-mediated lysis than the Major Histocompatibility Complex (MHC) class-I null target cell K562, and can suppress NK secretion of interferon-γ (IFN-γ). Moreover, as third-party cells, PDMCs suppress the cytotoxic effects of cytokine-stimulated NKs on K562. Pretreatment of PDMCs with IFN-γ, a proinflammatory cytokine, surprisingly enhances such immunosuppressive effects. Cell-cell contact between NKs and PDMCs is required for suppressive effects, which are partially mediated by slight up-regulation of the NK inhibitory receptor Killer Inhibitory Receptor and down-regulation of the activating receptor NKp30. Moreover, enhancement of the suppressive effects of PDMCs is also mediated by IFN-γ-induced surface expression of HLA-G-an immunomodulatory non-classical MHC class I molecule-on PDMCs, as seen by partial reversibility with HLA-G neutralizing antibodies. With its broad immunosuppressive properties, PDMCs may represent a potential cell source for therapeutic use.
    日期: 2011-06
    關聯: Cell Transplant. 2011 Jun;20(11-12):1721-1730.
    Link to: http://dx.doi.org/10.3727/096368911X580590
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0963-6897&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000300962400005
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84863011834
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