國家衛生研究院 NHRI:Item 3990099045/5377
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    題名: Analysis of global methylation using a Zta-expressing nasopharyngeal carcinoma cell line
    作者: Chen, YF;Tung, CL;Chang, Y;Hsiao, WC;Su, LJ;Sun, HS
    貢獻者: Division of Infectious Diseases
    摘要: EBV infects more than 90% of the human population and persists in most individuals as a latent infection where the viral genome is silenced by host-driven methylation. The lytic cycle is initiated when the viral protein Zta binds to methylated BRLF1 and BRRF1 promoters. Although studies reveal the role of Zta and methylation changes in the viral genome upon EBV infection to reactivation, whether Zta plays any role in alteration of methylation in the host genome remains unknown. Using an inducible model, we demonstrate that global DNA methylation, based on whole-genome 5-methylcytosine content, and regional DNA methylation in repetitive elements, imprinting genes and the X chromosome, remains unchanged in response to Zta expression. Expression of DNA methyltransferases was also unaffected by ectopically expressed Zta. Our data imply that alteration of host gene expression following EBV reactivation may reflect methylation-independent Zta-mediated gene activation and not epigenetic modification of the host genome.
    日期: 2011-04
    關聯: Genomics. 2011 Apr;97(4):205-213.
    Link to: http://dx.doi.org/10.1016/j.ygeno.2010.12.003
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0888-7543&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000289047100003
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79952815437
    顯示於類別:[蘇益仁(2002-2015)] 期刊論文
    [張堯] 期刊論文

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