國家衛生研究院 NHRI:Item 3990099045/5389
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/5389


    Title: Long-term peptic ulcer rebleeding risk estimation in patients undergoing haemodialysis: a 10-year nationwide cohort study
    Authors: Wu, CY;Wu, MS;Kuo, KN;Wang, CB;Chen, YJ;Lin, JT
    Contributors: Division of Health Policy Research and Development
    Abstract: Objective We aimed to study 1-, 5- and 10-year risks of peptic ulcer rebleeding among end-stage renal disease (ESRD) patients with regular haemodialysis, to identify the high-risk subpopulation, and to estimate the number needed to harm (NNH) to increase a peptic ulcer rebleeding in different periods.Design A nationwide cohort study.Setting Data from the Taiwan National Health Insurance Research Database.Patients Uraemic cohort and matched controls were selected from among hospitalised patients with a primary diagnosis of peptic ulcer bleeding. In total, 6447 uraemic patients and 25?788 age-, gender- and gastroprotective agent use-matched controls were selected.Intervention No.Main outcome measures Cumulative incidences and HRs.Results The cumulative incidences of ESRD patients were significantly higher than the cumulative incidences of matched controls (1?year: 18.8% vs 14.2%; 5?years: 38.5% vs 31.4%; and 10?years: 46.3% vs 39.4%; all p<0.001). The NNH to increase a peptic ulcer rebleeding by ESRD at 1, 5 and 10?years were 22, 15 and 15, respectively. On multivariate analysis, ESRD (HR=1.38, p<0.0001) was an independent risk factor for rebleeding. Compared with matched controls, ESRD was associated with higher risk of rebleeding especially in patients using ulcerogenic agents (HR=1.33–1.45), indication to prescribe gastroprotective agents (HR=1.44) and with liver cirrhosis (HR=1.45).Conclusions ESRD patients had higher long-term risk of peptic ulcer rebleeding, especially in certain populations. The enhanced risk gradually decreased after the first year and stabilised after the fifth year.
    Date: 2011-08
    Relation: Gut. 2011 Aug;60(8):1038-1042.
    Link to: http://dx.doi.org/10.1136/gut.2010.224329
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0017-5749&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000292318200005
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79960321606
    Appears in Collections:[Ken-Nan Kuo] Periodical Articles

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