國家衛生研究院 NHRI:Item 3990099045/5404
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12189/12972 (94%)
造訪人次 : 956958      線上人數 : 840
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/5404


    題名: Kinetic studies on the interaction between EGFR and EGF and its traditional Chinese medicine-modulation by surface plasmon resonance
    其他題名: 3rd International Conference on BioMedical Engineering and Informatics, BMEI 2010
    作者: Dong, GC;Yao, CH
    貢獻者: Division of Medical Engineering Research
    摘要: Epidermal growth factor receptor (EGFR) is an important target on cancer therapy. One of the approaches is to modulate EGFR induced ligand-binding affinity change. In order to understand the correlation between ligand-binding change and EGFR modulation, we try to get some small molecular agents from traditional Chinese medicines (TCMs) to modulate EGFR activity on the biosensor system. Among 60 of TCMs, we find that some samples exhibit different influence on EGFR modulation. Among these, 051 showed a more inhibitive property due to decreasing EGF-affinity, -binding to EGFR and existed an anti-EGFR activity to A549 cells. On the other hand, 040 exist opposite function to 051. 040 is a most powerful enhancer that can increase the affinity and quantity of EGF binding to EGFR and a pro-EGFR activity on cell culture system. In our study, we can successfully regulate the EGFR-mediated cell proliferation and anti-apoptosis by modulating the affinity of EGF-EGFR interaction. This way will be a useful method to apply on the therapy of human diseases.
    日期: 2010-10-16
    關聯: Biomedical Engineering and Informatics (BMEI), 2010 3rd International Conference on. 2010 Oct 16-18;6:2415-2417(Article number 5639783).
    Link to: http://dx.doi.org/10.1109/BMEI.2010.5639783
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=78650660615
    顯示於類別:[董國忠] 會議論文/會議摘要

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    SCP78650660615.pdf302KbAdobe PDF813檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋