國家衛生研究院 NHRI:Item 3990099045/5424
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    题名: A community effort towards a knowledge-base and mathematical model of the human pathogen Salmonella Typhimurium LT2
    作者: Thiele, I;Hyduke, DR;Steeb, B;Fankam, G;Allen, DK;Bazzani, S;Charusanti, P;Chen, FC;Fleming, RMT;Hsiung, CA;De Keersmaecker, SCJ;Liao, YC;Marchal, K;Mo, ML;Ozdemir, E;Raghunathan, A;Reed, JL;Shin, SI;Sigurbjornsdottir, S;Steinmann, J;Sudarsan, S;Swainston, N;Thijs, IM;Zengler, K;Palsson, BO;Adkins, JN;Bumann, D
    贡献者: Division of Biostatistics and Bioinformatics
    摘要: Background: Metabolic reconstructions (MRs) are common denominators in systems biology and represent biochemical, genetic, and genomic (BiGG) knowledge-bases for target organisms by capturing currently available information in a consistent, structured manner. Salmonella enterica subspecies I serovar Typhimurium is a human pathogen, causes various diseases and its increasing antibiotic resistance poses a public health problem. Results: Here, we describe a community-driven effort, in which more than 20 experts in S. Typhimurium biology and systems biology collaborated to reconcile and expand the S. Typhimurium BiGG knowledge-base. The consensus MR was obtained starting from two independently developed MRs for S. Typhimurium. Key results of this reconstruction jamboree include i) development and implementation of a community-based workflow for MR annotation and reconciliation; ii) incorporation of thermodynamic information; and iii) use of the consensus MR to identify potential multi-target drug therapy approaches. Conclusion: Taken together, with the growing number of parallel MRs a structured, community-driven approach will be necessary to maximize quality while increasing adoption of MRs in experimental design and interpretation.
    日期: 2011-01
    關聯: BMC Systems Biology. 2011 Jan;5:Article number 8.
    Link to: http://dx.doi.org/10.1186/1752-0509-5-8
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000286822100001
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=78651467275
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