國家衛生研究院 NHRI:Item 3990099045/5436
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    題名: Involvement of 14-3-3 gamma overexpression in extrahepatic metastasis of hepatocellular carcinoma
    其他題名: Involvement of 14-3-3γ overexpression in extrahepatic metastasis of hepatocellular carcinoma
    作者: Ko, BS;Lai, IR;Chang, TC;Liu, TA;Chen, SC;Wang, J;Jan, YJ;Liou, JY
    貢獻者: Institute of Cellular and Systems Medicine
    摘要: The 14-3-3 gamma protein is an important regulator of various cellular and physiologic functions Overexpression promotes cell proliferation and induces cancer cell polyploidization Production is up regulated in human hepatocellular carcinoma However, the clinical significance of 14 3 3 gamma for human hepatocellular carcinoma metastasis and survival has not been clarified In this study, 55 patients with human hepatocellular carcinoma were enrolled, and 18 of them were identified as having extrahepatic metastases Expression of 14 3-3 gamma in these primary and metastatic samples was measured with semiquantitative immunohistochemistry analysis Overexpression of 14 3-3 gamma was observed in 38 (69 1%) of the primary tumors correlated significantly with a high alpha-fetoprotein concentration (P = 003), and predicted a higher probability of extrahepatic metastasis (cumulative probabilities at 5 years 42 2% +/- 8 0% versus 5 9% +/- 5 7%, 14-3-3 gamma positive versus negative, P = 012) Furthermore, 14-3 3 gamma overexpression was associated with a worse 5-year overall survival rate (81 6% +/- 9 6% versus 59 5% +/- 8 1%, respectively) and a worse 5-year progression-free survival rate (75 6% +/- 106% versus 48 6% +/- 8 2% respectively) Elevated expression of 14 3-3 gamma in human hepatocellular carcinoma predicts extrahepatic metastasis and worse survival The protein thus is a candidate biomarker and a potential target for novel therapies against human hepatocellular carcinoma progression and metastasis
    日期: 2011-01
    關聯: Human Pathology. 2011 Jan;42(1):129-135.
    Link to: http://dx.doi.org/10.1016/j.humpath.2010.01.028
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0046-8177&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000285527600016
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=78650001931
    顯示於類別:[劉俊揚] 期刊論文

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