國家衛生研究院 NHRI:Item 3990099045/5461
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/5461


    Title: Association between insulin resistance and development of microalbuminuria in type 2 diabetes: a prospective cohort study
    Authors: Hsu, CC;Chang, HY;Huang, MC;Hwang, SJ;Yang, YC;Tai, TY;Yang, HJ;Chang, CT;Chang, CJ;Li, YS;Shin, SJ;Kuo, KN
    Contributors: Division of Health Services and Preventive Medicine
    Abstract: OBJECTIVE An association between insulin resistance and microalbuminuria in type 2 diabetes has often been found in cross-sectional studies. We aimed to reassess this relationship in a prospective Taiwanese cohort of type 2 diabetic subjects. RESEARCH DESIGN AND METHODS We enrolled 738 normoalbuminuric type 2 diabetic subjects, aged 56.6 +/- 9.0 years, between 2003 and 2005 and followed them through the end of 2009. Average follow-up time was 5.2 +/- 0.8 years. We used urine albumin-to-creatinine ratio to define microalbuminuria and the homeostasis model assessment for insulin resistance (HOMA-IR) to assess insulin resistance. The incidence rate ratio and Cox proportional hazard model were used to evaluate the association between HOMA-IR and development of microalbuminuria. RESULTS We found incidences of microalbuminuria of 64.8, 83.5, 93.3, and 99.0 per 1,000 person-years for the lowest to highest quartiles of HOMA-IR. Compared with those in the lowest quartile of HOMA-IR, the incidence rate ratio for those in the 2nd, 3rd, and highest quartiles were 1.28 (95% CI 0.88-1.87), 1.44 (0.99-2.08), and 1.52 (1.06-2.20), respectively (trend test: P < 0.001). By comparison with those in the lowest quartile, the adjusted hazard ratios were 1.37 (0.93-2.02), 1.66 (1.12-2.47), and 1.76 (1.20-2.59) for those in the 2nd, 3rd, and highest HOMA-IR quartiles, respectively. CONCLUSIONS According to the dose-response effects of HOMA-IR shown in this prospective study, we conclude that insulin resistance could significantly predict development of microalbuminuria in type 2 diabetic patients.
    Date: 2011-04
    Relation: Diabetes Care. 2011 Apr;34(4):982-987.
    Link to: http://dx.doi.org/10.2337/dc10-1718
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0149-5992&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000289221800033
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79956213390
    Appears in Collections:[Chih-Cheng Hsu] Periodical Articles
    [Ken-Nan Kuo] Periodical Articles
    [Hsing-Yi Chang] Periodical Articles

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