國家衛生研究院 NHRI:Item 3990099045/5504
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12189/12972 (94%)
造訪人次 : 966244      線上人數 : 848
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/5504


    題名: Isatin-beta-thiosemicarbazones as potent herpes simplex virus inhibitors
    其他題名: Isatin-β-thiosemicarbazones as potent herpes simplex virus inhibitors
    作者: Kang, IJ;Wang, LW;Hsu, TA;Yueh, A;Lee, CC;Lee, YC;Lee, CY;Chao, YS;Shih, SR;Chern, JH
    貢獻者: Institute of Biotechnology and Pharmaceutical Research
    摘要: A series of isatin-beta-thiosemicarbazones have been designed and evaluated for antiviral activity against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in a plaque reduction assay. Their cytotoxicity was examined using human rhabdomyosarcoma cells (RD cells). Several derivatives of isatin-beta-thiosemicarbazone exhibited significant and selective antiviral activity with low cytotoxicity. It was found that the thiourea group at thiosemicarbazone and the NH functionality at isatin were essential for their anti-herpetic activity. The synthesis and structure-activity relationship studies are presented.
    日期: 2011-04
    關聯: Bioorganic and Medicinal Chemistry Letters. 2011 Apr;21(7):1948-1952.
    Link to: http://dx.doi.org/10.1016/j.bmcl.2011.02.037
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0960-894X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000288245100008
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79952484386
    顯示於類別:[徐祖安] 期刊論文
    [陳志豪] 期刊論文
    [岳嶽] 期刊論文
    [趙宇生(2002-2013)] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    ISI000288245100008.pdf694KbAdobe PDF915檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋