國家衛生研究院 NHRI:Item 3990099045/5544
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/5544


    Title: Synthesis and biological evaluation of 4-aroyl-6,7,8-trimethoxyquinolines as a novel class of anticancer agents
    Authors: Hsieh, CC;Lee, HY;Nien, CY;Kuo, CC;Chang, CY;Chang, JY;Liou, JP
    Contributors: National Institute of Cancer Research
    Abstract: A series of 2-aroyl and 2-aryl-5,6,7-trimethoxyquinoline and 4-aroyl-6,7,8-trimethoxyquinoline combretastatin analogs were synthesized and evaluated for their potential anticancer activity. The 4-aroylquinoline 11 inhibited the growth of the human cancer cells lines KB, HT-29, and MKN45, as well as the three human resistant cancer cell lines KB-vin10, KB-S15, and KB-7D, with IC(50) values of 217, 327, 239, 246, 213, and 252 nM, respectively.
    Date: 2011-03-07
    Relation: Molecules. 2011 Mar 7;16(3):2274-2284.
    Link to: http://dx.doi.org/10.3390/molecules16032274
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1420-3049&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000288853400024
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79953115506
    Appears in Collections:[Jang-Yang Chang] Periodical Articles
    [Ching-Chuan Kuo] Periodical Articles

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