國家衛生研究院 NHRI:Item 3990099045/5580
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    题名: Nucleotide Sequence Divergence between Humans and Chimpanzees
    作者: Chen, FC;Chuang, TJ
    贡献者: Division of Biostatistics and Bioinformatics
    摘要: Chimpanzee, as the closest relative of human, has long been a focus of molecular evolution. In this article, we review recent findings of five major categories of human–chimpanzee genomic divergence, namely nucleotide substitution, insertion/deletion, duplication, pseudogenization and rearrangement. It is demonstrated that nonsubstitution variations greatly increase the complexity and play a critical role in human–chimpanzee genome evolution. These genetic changes may provide some clues to the evolutionary origins of human-specific traits.
    日期: 2008-03
    Link to: http://dx.doi.org/10.1002/9780470015902.a0020751
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