國家衛生研究院 NHRI:Item 3990099045/5602

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Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/5602

Title:	Cancer-targeted BikDD gene therapy elicits protective antitumor immunity against lung cancer
Authors:	Sher, YP;Liu, SJ;Chang, CM;Lien, SP;Chen, CH;Han, ZB;Li, LY;Chen, JS;Wu, CW;Hung, MC
Contributors:	Vaccine Research and Development Center
Abstract:	Targeted cancer-specific gene therapy is a promising strategy for treating metastatic lung cancer, which is a leading cause of lung cancer-related deaths. Previously, we developed a cancer-targeted gene therapy expression system with high tumor specificity and strong activity that selectively induced lung cancer cell killing without affecting normal cells in immunocompromised mice. Here, we found this cancer-targeted gene therapy, SV-BikDD, composed of the survivin promoter in the VP16-GAL4-WPRE integrated systemic amplifier system to drive the apoptotic gene BikDD, not only caused cytotoxic effects in cancer cells but also elicited a cancer-specific cytotoxic T lymphocyte response to synergistically increase the therapeutic effect and further develop an effective systemic antitumoral immunity against rechallenges of tumorigenic dose of parental tumor cells inoculated at distant sites in immunocompetent mice. In addition, this cancer-targeted gene therapy does not elicit an immune response against normal tissues, but CMV-BikDD treatment does. The therapeutic vector could also induce proinflammatory cytokines to activate innate immunity and provide some benefits in antitumor gene therapy. Thus, this study provides a promising strategy with benefit of antitumoral immune response worthy of further development in clinical trials for treating lung cancer via cancer-targeted gene therapy.
Date:	2011-04
Relation:	Molecular Cancer Therapeutics. 2011 Apr;10(4):637-647.
Link to:	http://dx.doi.org/10.1158/1535-7163.mct-10-0827
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1535-7163&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000289229300007
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79955763145
Appears in Collections:	[Shih-Jen Liu] Periodical Articles

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