國家衛生研究院 NHRI:Item 3990099045/5700
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    题名: Chloroacetaldehyde induces chromosome aberrations and micronucleus formation but not 2-chloroethanol
    作者: Liao, JW;Hsu, CI;Matsuura, I;Chen, YT
    贡献者: Institute of Molecular and Genomic Medicine
    摘要: 2-Chloroethanol (2-CE) has been used on grapevines to accelerate grape growth, and its metabolite, chloroacetaldehyde (CAA), accumulated in the liver and blood from rats intoxicated with 2-CE. Chronic occupational injury might be a possible reason for the 2-CE intoxication. In this study, we used the in vitro and in vivo tests to examine the genotoxicity of 2-CE and CAA. First, 2-CE did not induce chromosome aberration formation in Chinese ovary hamster cells, but CAA did induce chromosome aberration formation, especially the chromosome gap-type aberration after S9 activation. Second, 2-CE at high doses (1/2 LD50), but not at low doses, induced peripheral blood micronucleus formation in mice. CAA induced micronucleus formation at low and high dosages (1/8-1/2 LD50). These results indicated that CAA plays an important role in 2-CE chronic intoxication, and the genotoxic mechanisms of CAA require further study.
    日期: 2011-06
    關聯: Journal of Health Science. 2011 Jun;57(3):300-303.
    Link to: http://jhs.pharm.or.jp/data/57%283%29/57_300.htm
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000291085800011
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79958030076
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