國家衛生研究院 NHRI:Item 3990099045/5702
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    题名: IL-10 promoter genetic polymorphisms and risk of Kawasaki disease in Taiwan
    作者: Hsieh, KS;Lai, TJ;Hwang, YT;Lin, MW;Weng, KP;Chiu, YT;Ho, TY;Chen, CS;Shiue, YL;Hsiao, M;Tsai, SF;Ger, LP
    贡献者: Institute of Molecular and Genomic Medicine
    摘要: Kawasaki disease (KD) is the most common cause of pediatric acquired heart disease. KD patients have spontaneously high plasma/serum levels of IL-10 during the acute phase. Therefore, two independent studies were carried out to investigate the association between genetic variants in IL-10 promoter (-1082,-819, and-592) and risk of KD. A total of 134 trios were included for the family-based association study. A significantly preferential transmission of the C allele at loci-819 T > C and-592 A > C for KD cases was observed (Ppermutation = 0.029 and Ppermutation = 0.034, respectively). There was a significant increase in the transmission of haplotype CC (p = 0.016) at the above two loci (OR, 1.632; 95% CI, 1.090-2.443; P permutation = 0.019). We also carried out a follow-up case-control study that included 146 KD cases and 315 unrelated healthy children. The haplotype CC (-819,-592) showed an increased risk of KD (but statistically non-significant; OR, 1.332; 95% CI, 0.987-1.797; p = 0.061). In diplotype analysis, a trend was found between number of CC haplotype and risk of KD (but non-significant, p =0.061). In conclusion, CC genotype and CC/CC diplotype at IL-10-819T > C and-592A > C were significantly associated with risk of KD in case-parent trio study, which were replicated partially in our follow-up case-control study.
    日期: 2011-04
    關聯: Disease Markers. 2011 Apr;30(1):51-59.
    Link to: http://dx.doi.org/10.3233/dma-2011-0765
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000290961500006
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79955115477
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