國家衛生研究院 NHRI:Item 3990099045/5725
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    题名: Association of blood monocyte and platelet markers with carotid artery characteristics: The atherosclerosis risk in communities carotid MRI study
    作者: Matijevic, N;Wu, KK;Howard, AG;Wasserman, B;Wang, WYW;Folsom, AR;Sharrett, AR
    贡献者: Institute of Cellular and Systems Medicine
    摘要: Background: Atherosclerosis is characterized by infiltration of inflammatory cells from circulating blood. Blood cell activation could play an important role in plaque formation. Methods: We analyzed the relationship between blood cellular markers and quantitative measures of carotid wall components in 1,546 participants from the ARIC (Atherosclerosis Risk in Communities) Carotid MRI Study. Carotid imaging was performed using a gadolinium contrast-enhanced MRI and cellular phenotyping by flow cytometry. Results: Monocyte Toll-like receptor (TLR)-2 is associated with larger plaques, while CD14, myeloperoxidase, and TLR-4 associate with smaller. Platelet CD40L is associated with smaller plaques and thinner caps, while P-selectin is associated with smaller core size. Conclusions: Blood cell activation is significantly associated with atherosclerotic changes of the carotid wall.
    日期: 2011-05
    關聯: Cerebrovascular Diseases. 2011 May;31(6):552-558.
    Link to: http://dx.doi.org/10.1159/000324389
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1015-9770&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000291818800004
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79953767177
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