國家衛生研究院 NHRI:Item 3990099045/5731

NHRI > National Institute of Infectious Diseases and Vaccinology > Yao Chang > Periodical Articles > Item 3990099045/5731

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/5731

Title:	Human papilloma virus detection in neoplastic and non-neoplastic nasopharyngeal tissues in Taiwan
Authors:	Huang, CC;Hsiao, JR;Yang, MW;Wu, YH;Hsu, KF;Chang, Y;Chen, CW;Tsai, ST;Wei, HP;Jin, YT
Contributors:	Division of Infectious Diseases
Abstract:	Background: Human papilloma virus (HPV) has been implicated in the carcinogenesis and prognosis of certain head and neck cancers. Whether it also has a role in the pathogenesis of nasopharyngeal carcinoma (NPC) in Taiwan is unclear. Methods: Detection and genotyping of HPVs were performed in 43 primary NPCs (one WHO-I and 42 WHO-II/III) and 40 nasopharyngeal controls using PCR-based HPV genotyping arrays. Localisation of high-risk HPV and Epstein-Barr virus genomes was performed in another 46 primary NPCs (five WHO-I and 41 WHO-II/III) and seven paired metastatic WHO-II/III NPCs using in situ hybridisation. Results: In the HPV genotyping cohort, oncogenic HPVs were detected equally in WHO-II/III NPCs (31%, 13/42) and nasopharyngeal controls (35%, 14/40). Tumour high-risk HPV status did not correlate with the prognosis of patients with NPC. In the high-risk HPV in situ hybridisation cohort, 14 (88%) of the 16 oncogenic HPV-positive WHO-II/III NPCs showed a unique cytoplasmic/perinuclear staining pattern, which is distinct from the typical dot/punctate nuclear staining pattern indicating HPV genome integration. In addition, oncogenic HPVs were not always retained in NPC cells during the process of metastasis. Conclusions: This study does not support an association between oncogenic HPV and the carcinogenesis or prognosis of WHO-II/III NPCs in Taiwan.
Date:	2011-07
Relation:	Journal of Clinical Pathology. 2011 Jul;64(7):571-577.
Link to:	http://dx.doi.org/10.1136/jcp.2010.087742
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0021-9746&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000291719800004
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79959333941
Appears in Collections:	[Yao Chang] Periodical Articles

Files in This Item:

File	Description	Size	Format
SCP79955003372.pdf		1345Kb	Adobe PDF	640	View/Open

Loading...