國家衛生研究院 NHRI:Item 3990099045/5733

NHRI > National Institute of Infectious Diseases and Vaccinology > Ih-Jen Su(2002-2015) > Periodical Articles > Item 3990099045/5733

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/5733

Title:	Genomic instability caused by hepatitis B virus: Into the hepatoma inferno
Authors:	Hsieh, YH;Hsu, JL;Su, IJ;Huang, WY
Contributors:	Division of Infectious Diseases
Abstract:	Chronic hepatitis B virus (HBV) infection is an important cause of hepatocellular carcinoma (HCC) worldwide, especially in Asia. HBV induces HCC through multiple oncogenic pathways. Hepatitis-induced hepatocyte inflammation and regeneration stimulates cell proliferation. The interplay between the viral and host factors activates oncogenic signaling pathways and triggers cell transformation. In this review, we summarize previous studies, which reported that HBV induces host genomic instability and that HBV-induced genomic instability is a significant factor that accelerates carcinogenesis. The various types of genomic changes in HBV-induced HCC-chromosomal instability, telomere attrition, and gene-level mutations-are reviewed. In addition, the two viral factors, HBx and the pre-S2 mutant large surface antigen, are discussed for their roles in promoting genomic instability as their main features as viral oncoproteins.
Date:	2011-06
Relation:	Frontiers in Bioscience. 2011 Jun;16(7):2586-2597.
Link to:	http://dx.doi.org/10.2741/3874
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2768-6701&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000290097400013
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79959557402
Appears in Collections:	[Ih-Jen Su(2002-2015)] Periodical Articles

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