國家衛生研究院 NHRI:Item 3990099045/5751
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/5751


    Title: Antimutagenic constituents of adlay ( Coix lachryma-jobi L. var. ma-yuen Stapf) with potential cancer chemopreventive activity
    Authors: Chen, HH;Chiang, W;Chang, JY;Chien, YL;Lee, CK;Liu, KJ;Cheng, YT;Chen, TF;Kuo, YH;Kuo, CC
    Contributors: National Institute of Cancer Research
    Abstract: Adlay has long been used in traditional Chinese medicine and as a nourishing food. The acetone extract of adlay hull had previously been demonstrated to possess potent antimutagenic activity. The aims of this study were to identify the antimutagenic constituents from adlay hull by using Ames antimutagenic activity-guide isolation procedures and to investigate their chemopreventive efficacies in cultured cells. The results demonstrated that six compounds showing great antimutagenic activity were identified by spectroscopic methods and by comparison with authentic samples to be p-hydroxybenzaldehyde, vanillin, syringaldehyde, trans-coniferylaldehyde, sinapaldehyde, and coixol. Two of them, trans-coniferylaldehyde and sinapaldehyde, exhibit relatively potent scavenging of DPPH radicals, inhibit TPA stimulated superoxide anion generation in neutrophil-like leukocytes, and induce Nrf2/ARE-driven luciferase activity in HSC-3 cells. Moreover, trans-coniferylaldehyde possesses cytoprotective efficacy against tert-butyl hydroperoxide-induced DNA double-strand breaks in cultured cells, and the chemopreventive potency induced by trans-coniferylaldehyde may be through the activation of kinase signals, including p38, ERK1/2, JNK, MEK1/2, and MSK1/2. In summary, we first identified six antimutagenic constituents from adlay hull. Among them, trans-coniferylaldehyde would be a highly promising agent for cancer chemoprevention and merits further investigation.
    Date: 2011-06
    Relation: Journal of Agricultural and Food Chemistry. 2011 Jun;59(12):6444-6452.
    Link to: http://dx.doi.org/10.1021/jf200539r
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0021-8561&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000291568300012
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79959224748
    Appears in Collections:[Ching-Chuan Kuo] Periodical Articles
    [Ko-Jiunn Liu] Periodical Articles
    [Jang-Yang Chang] Periodical Articles

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