國家衛生研究院 NHRI:Item 3990099045/5795
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    題名: Diosgenin ameliorates cognition deficit and attenuates oxidative damage in senescent mice induced by D-Galactose
    作者: Chiu, CS;Chiu, YJ;Wu, LY;Lu, TC;Huang, TH;Hsieh, MT;Lu, CY;Peng, WH
    貢獻者: Division of Vaccine Research and Development
    摘要: This study attempted to access the neuroprotective effect of diosgenin on the senescent mice induced by d-galactose (D-gal). The mice in the experiments were orally administered with diosgenin (1, 5, 25 and 125 mg/kg), for four weeks from the sixth week. The learning and memory abilities of the mice in Morris water maze test and the mechanism involved in the neuroprotective effect of diosgenin on the mice brain tissue were investigated. Diosgenin (5, 25 and 125 mg/kg, p.o.) showed significantly improved learning and memory abilities in Morris water maze test compared to D-gal treated mice (200 mg/kg, ten weeks). Diosgenin also increased the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), and decreased the malondialdehyde (MDA) level in the brain of D-gal treated mice. These results indicated that diosgenin has the potential to be a useful treatment for cognitive impairment. In addition, the memory enhancing effect of diosgenin may be partly mediated via enhancing endogenous antioxidant enzymatic activities.
    日期: 2011-06
    關聯: American Journal of Chinese Medicine. 2011 Jun;39(3):551-563.
    Link to: http://dx.doi.org/10.1142/s0192415x11009020
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0192-415X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000290857500011
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79957497980
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