國家衛生研究院 NHRI:Item 3990099045/5816
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    题名: Enhancement of non-homologous end joining DNA repair capacity confers cancer cells resistance to the novel selenophene compound, D-501036
    作者: Yang, YN;Chou, KM;Pan, WY;Chen, YW;Tsou, TC;Yeh, SC;Cheung, CH;Chen, LT;Chang, JY
    贡献者: National Institute of Cancer Research;Division of Environmental Health and Occupational Medicine
    摘要: D-501036 is a promising anti-cancer compound that exhibits potent anti-proliferative activity against various types of human cancers through the induction of double strand DNA breaks. To determine drug resistance mechanism related to this class of DNA-damaging agents, a KB-derived D-501036-resistant cell line (S4) was established. Results showed that S4 cells exhibit enhanced DNA rejoining ability as compare to KB cells, through up-regulation of the non-homologous end joining activity. In conclusion, enhancement of NHEJ activity plays important role in the development of D-501036-resistance and targeting NHEJ-related molecules maybe able to overcome drug resistance to DNA damaging agents.
    日期: 2011-10-01
    關聯: Cancer Letters. 2011 Oct 1;309(1):110-118.
    Link to: http://dx.doi.org/10.1016/j.canlet.2011.05.023
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0304-3835&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000293491200014
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79959836483
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