國家衛生研究院 NHRI:Item 3990099045/5837
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    题名: Analysis of the structure-activity relationships between phenanthroindolizidines and phenanthroquinolizidines
    作者: Lee, SJ;Yang, CW;Chuang, TH;Wu, PL
    贡献者: Institute of Biotechnology and Pharmaceutical Research
    摘要: Phenanthroindolizidines and phenanthroquinolizidines are structure-related alkaloids that are well known for their profound cytotoxicity toward a variety of cancer cells and thus have been explored to develop into anti-cancer agents. Tylophorine and cryptoleurine are representative of these two classes of alkaloids respectively. While tylophorine was conceivable to account for the anti-inflammation related effects for Tylophora indica and has been reported to exert significant anti-inflammatory effects in vitro and in vivo, not much known for cryptoleurine and its analogues for anti-inflammation related effects. Although over 70 of phenanthroindolizidine, phenanthroquinolizidine alkaloids, and their analogues have been purified or synthesized, systemic analyses for the structure-activity relationships are needed for more clear elucidation between or among the phenanthroindolizidines and phenanthroquinolizidines. Thus, We synthesized 16 compounds of phenanthroindolizidines (8 compounds, 2 sets) and their counterparts of phenanthroquinolizidines(8 compounds, 2 sets). We analyzed the relationships between the structures and activities of anti-cancer cell growth and anti-inflammation in in vitro systems and also probed the differential activity between and among the phenanthroindolizidines and phenanthroquinolizidines.
    日期: 2006-04
    關聯: FASEB Journal. 2006 Apr 1-5;20(5):LB492.
    Link to: http://www.fasebj.org/cgi/content/meeting_abstract/20/5/LB108-c
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0892-6638&DestApp=IC2JCR
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