國家衛生研究院 NHRI:Item 3990099045/5844
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    题名: Isolation and biological activities of phenanthroindolizidine and septicine alkaloids from the formosan tylophora ovata
    作者: Lee, YZ;Huang, CW;Yang, CW;Hsu, HY;Kang, IJ;Chao, YS;Chen, IS;Chang, HY;Lee, SJ
    贡献者: Institute of Biotechnology and Pharmaceutical Research
    摘要: An investigation of alkaloids present in the leaves and stems of Tylophora ovata led to the isolation of two new septicine alkaloids and one new phenanthroindolizidine alkaloid, tylophovatines A, B, C (1, 2, and 5), respectively, together with two known septicine and six known phenanthroindolizidine alkaloids. The structures of the new alkaloids 1, 2, and 5 were established by means of spectroscopic analyses. These eleven alkaloids show in vitro anti-inflammatory activities with IC50 values ranging from 84 nM to 20.6 μM through their suppression of nitric oxide production in RAW 264.7 cells stimulated by lipopolysaccharide and interferon-γ. Moreover, these substances display growth inhibition in HONE-1, NUGC-3, HepG2, SF-268, MCF-7, and NCI-H460 cancer cell lines, with GI50 values ranging from 4 nM to 24.2 μM. In addition, tylophovatine C (5) and 13a(S)-(+)-tylophorine (7) were found to exhibit potent in vivo anti-inflammation activities in a rat paw edema model. Finally, structure-activity relationships were probed by using the isolated phenanthroindolizidines and septicines. Phenanthroindolizidines are suggested to be divided into cytotoxic agents (e.g., 10 and 11) and anti-inflammation based anticancer agents (e.g., 5-9).
    日期: 2011-11
    關聯: Planta Medica. 2011 Nov;77(17):1932-1938.
    Link to: http://dx.doi.org/10.1055/s-0030-1271199
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0032-0943&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000298851200011
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=81855217515
    显示于类别:[李秀珠] 期刊論文
    [趙宇生(2002-2013)] 期刊論文

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