國家衛生研究院 NHRI:Item 3990099045/5851

NHRI > Institute of Biomedical Engineering and Nanomedicine > Chung-Shi Yang > Periodical Articles > Item 3990099045/5851

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/5851

Title:	Aptamer-conjugated DNA icosahedral nanoparticles as a carrier of doxorubicin for cancer therapy
Authors:	Chang, M;Yang, CS;Huang, DM
Contributors:	Center for Nanomedicine Research
Abstract:	DNA can be used to nanofabricate three-dimensional (3D) polyhedra. A variety of applications of 3D DNA assemblies have been proposed. Drug encasulation and intracellular delivery using DNA nanoparticles, however, have remained a challenge. Here, we create a distinct five-point-star motif and aptamer-conjugated six-point-star motif using well-used primer sequences to intermolecularly construct DNA icosahedra as a nanocarrier for doxorubicin. Aptamer-conjugated doxorubicin-intercalated DNA icosahedra (Doxo@Apt-DNA-icosa) show an efficient and specific internalization for killing epithelial cancer cells.
Date:	2011-08
Relation:	ACS Nano. 2011 Aug;5(8):6156-6163.
Link to:	http://dx.doi.org/10.1021/nn200693a
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1936-0851&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000294085400012
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=80052040413
Appears in Collections:	[Chung-Shi Yang] Periodical Articles [Dong-Ming Huang] Periodical Articles

Files in This Item:

File	Description	Size	Format
PB2011071811.pdf		4571Kb	Adobe PDF	904	View/Open