國家衛生研究院 NHRI:Item 3990099045/5859

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Title:	Easy strategy to increase salt resistance of antimicrobial peptides
Authors:	Yu, HY;Tu, CH;Yip, BS;Chen, HL;Cheng, HT;Huang, KC;Lo, HJ;Cheng, JW
Contributors:	Division of Infectious Diseases
Abstract:	The efficacies of many antimicrobial peptides are greatly reduced under high salt concentrations limiting their development as pharmaceutical compounds. Here, we describe an easy strategy to increase salt resistance of antimicrobial peptides by replacing tryptophan or histidine residues with the bulky amino acids {beta}-naphthylalanine and {beta}-(4,4' -biphenyl)alanine. The activities of the salt-sensitive peptide P-113 were diminished at high salt concentrations, whereas the activities of its {beta}-naphthylalanine and {beta}-(4,4' -biphenyl)alanine substituted variant were less affected.
Date:	2011-10
Relation:	Antimicrobial Agents and Chemotherapy. 2011 Oct;55(10):4918-4921.
Link to:	http://dx.doi.org/10.1128/aac.00202-11
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0066-4804&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000294952600060
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=80052850847
Appears in Collections:	[Hsiu-Jung Lo] Periodical Articles

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