國家衛生研究院 NHRI:Item 3990099045/5873
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    题名: Genetic variants in the folate pathway and risk of childhood acute lymphoblastic leukemia
    作者: Metayer, C;Scelo, G;Chokkalingam, AP;Barcellos, LF;Aldrich, MC;Chang, JS;Guha, N;Urayama, KY;Hansen, HM;Block, G;Kiley, V;Wiencke, JK;Wiemels, JL;Buffler, PA
    贡献者: National Institute of Cancer Research
    摘要: Objective: Folate is involved in the one-carbon metabolism that plays an essential role in the synthesis, repair, and methylation of DNA. We examined whether child's germline genetic variation in the folate pathway is associated with childhood acute lymphoblastic leukemia (ALL), and whether periconception maternal folate and alcohol intake modify the risk. Methods: Seventy-six single nucleotide polymorphisms (SNPs), including 66 haplotype-tagging SNPs in 10 genes (CBS, DHFR, FOLH1, MTHFD1, MTHFR, MTR, MTRR, SHMT1, SLC19A1, and TYMS), were genotyped in 377 ALL cases and 448 controls. Log-additive associations between genotypes and ALL risk were adjusted for age, sex, Hispanic ethnicity (when appropriate), and maternal race. Results: Single and haplotype SNPs analyses showed statistically significant associations between SNPs located in (or adjacent to) CBS,MTRR, TYMS/ENOFS, and childhood ALL. Many regions of CBS were associated with childhood ALL in Hispanics and non-Hispanics (p＜0.01). Levels of maternal folate intake modified associations with SNPs in CBS, MTRR, and TYMS. Conclusion: Our data suggest the importance of genetic variability in the folate pathway and childhood ALL risk.
    日期: 2011-09
    關聯: Cancer Causes and Control. 2011 Sep;22(9):1243-1258.
    Link to: http://dx.doi.org/10.1007/s10552-011-9795-7
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0957-5243&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000293296200003
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=80052330413
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