國家衛生研究院 NHRI:Item 3990099045/5876
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    题名: Hydrolysable tannins of tropical almond show antifibrotic effects in TGF-beta1-induced hepatic stellate cells
    其它题名: Hydrolysable tannins of tropical almond show antifibrotic effects in TGF-β1-induced hepatic stellate cells
    作者: Chuang, HY;Ng, LT;Lin, LT;Chang, JS;Chen, JY;Lin, TC;Lin, CC
    贡献者: National Institute of Cancer Research
    摘要: Background: Persistent activation of hepatic stellate cells (HSC-T6) has been known to cause liver fibrosis. In this study, our objective was to investigate the effects of chebulagic acid and chebulinic acid, two hydrolysable tannins of tropical almond (Terminalia chebula) fruits, on collagen synthesis and signal transduction in transforming growth factor-β1-stimulated HSC-T6 cells. The expression of Smad2, Smad3, Smad4, collagen I(α1)/III, and plasminogen activator inhibitor 1 (PAI-1) mRNAs was determined by reverse-transcription polymerase chain reaction and their protein levels were assessed by western blotting. Results: Results showed that chebulagic acid and chebulinic acid at 20 μmol L-1 exhibited cytotoxic and anti-proliferative effects on HSC-T6 cells. They also significantly decreased the expression of Smd2, Smad3 and Smad4, and the synthesis of collagen, procollagen I (α1) and III, as well as suppressing the activation of PAI-1; these events consequently facilitated the resolution of fibrosis. Conclusion: These results indicate that both chebulagic acid and chebulinic acid possess antifibrotic activity, and their mechanism of action could be through the inhibition of the Smad pathway.
    日期: 2011-12
    關聯: Journal of the Science of Food and Agriculture. 2011 Dec;91(15):2777-2784.
    Link to: http://dx.doi.org/10.1002/jsfa.4521
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-5142&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000297933400010
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=81155131183
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