國家衛生研究院 NHRI:Item 3990099045/5916
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    题名: A novel single-dose dengue subunit vaccine induces memory immune responses
    作者: Chiang, CY;Liu, SJ;Tsai, JP;Li, YS;Chen, MY;Liu, HH;Chong, P;Leng, CH;Chen, HW
    贡献者: Division of Vaccine Research and Development
    摘要: To protect against dengue viral infection, a novel lipidated dengue subunit vaccine was rationally designed to contain the consensus amino acid sequences derived from four serotypes of dengue viruses. We found that the lipidated consensus dengue virus envelope protein domain III (LcED III) is capable of activating antigen-presenting cells and enhancing cellular and humoral immune responses. A single-dose of LcED III immunization in mice without extra adjuvant formulation is sufficient to elicit neutralizing antibodies against all four serotypes of dengue viruses. In addition, strong memory responses were elicited in mice immunized with a single-dose of LcED III. Quick, anamnestic neutralizing antibody responses to a live dengue virus challenge were elicited at week 28 post-immunization. These results demonstrate the promising possibility of a future successful tetravalent vaccine against dengue viral infections that utilizes one-dose vaccination with LcED III.
    日期: 2011-08
    關聯: PLoS ONE. 2011 Aug;6(8):Article number e23319.
    Link to: http://dx.doi.org/10.1371/journal.pone.0023319
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1932-6203&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000293558900075
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79961081811
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