國家衛生研究院 NHRI:Item 3990099045/6055
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12145/12927 (94%)
造訪人次 : 859735      線上人數 : 797
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/6055


    題名: Increased expression of 14-3-3beta promotes tumor progression and predicts extrahepatic metastasis and worse survival in hepatocellular carcinoma
    其他題名: Increased Expression of 14-3-3β Promotes Tumor Progression and Predicts Extrahepatic Metastasis and Worse Survival in Hepatocellular Carcinoma
    作者: Liu, TA;Jan, YJ;Ko, BS;Chen, SC;Liang, SM;Hung, YL;Hsu, C;Shen, TL;Lee, YM;Chen, PF;Wang, J;Shyue, SK;Liou, JY
    貢獻者: Institute of Cellular and Systems Medicine
    摘要: 14-3-3beta is implicated in cell survival, proliferation, migration, and tumor growth; however, its clinical relevance in tumor progression and metastasis have never been elucidated. To evaluate the clinical significance of 14-3-3beta, we analyzed the association of 14-3-3beta expression and clinicopathologic characteristics in primary and subsequent metastatic tumors of hepatocellular carcinoma patients. 14-3-3beta was expressed abundantly in 40 of 55 (70.7%) primary tumors. Increased 14-3-3beta expression in primary tumors predicted a higher 5-year cumulative incidence of subsequent extrahepatic metastasis, and multivariate analysis revealed 14-3-3beta overexpression was an independent risk factor for extrahepatic metastasis. Patients with increased 14-3-3beta expression in primary tumors had worse 5-year overall survival rates, and 14-3-3beta overexpression was an independent prognostic factor on Cox regression analysis. Furthermore, stably overexpressed 14-3-3beta enhanced hepatocellular carcinoma cell migration and proliferation and increased anchorage-independent cell growth. In addition, in vivo study in a nude-mice model showed tumor formation significantly increased with 14-3-3beta overexpression. In conclusion, this is the first report to show that increased 14-3-3beta expression is associated with subsequent extrahepatic metastasis and worse survival rates, as well as cancer progression of hepatocellular carcinoma. Thus, 14-3-3beta may be a novel prognostic biomarker and therapeutic target in hepatocellular carcinoma.
    日期: 2011-12
    關聯: American Journal of Pathology. 2011 Dec;179(6):2698-2708.
    Link to: http://dx.doi.org/10.1016/j.ajpath.2011.08.010
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0002-9440&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000298307700004
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=81255199249
    顯示於類別:[劉俊揚] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    PUB21967815.pdf1621KbAdobe PDF699檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋